Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages
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منابع مشابه
Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages.
Endotoxin tolerance allows macrophages to produce large quantities of proinflammatory cytokines immediately after their contact with lipopolysaccharides (LPSs), but prevents their further production after repeated exposure to LPSs. While this response is known to prevent overproduction of proinflammatory cytokines, the mechanism through which endotoxin tolerance is established has not been iden...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2013
ISSN: 0022-2275
DOI: 10.1194/jlr.m042549